Topical wound oxygen therapy (TWO2)
Topical Wound Oxygen (TWO2®) therapy allows for targeted treatment, utilizing cyclical pressurized oxygen applied directly to the wound site.
Patients self-administer the therapy in the comfort of their own homes while watching TV or reading a book.
TWO2® therapy is indicated for acute or chronic wounds.*
TWO2® is backed by robust clinical evidence, including both a best-in-class Randomized Controlled Trial and Real-World Evidence studies.
1. 6X More likely to heal DFUs in 12 weeks, 6X Less likely DFUs recur at 12 months:
2. 88% Reduction in hospitalizations, 71% Reduction in amputations:
3. 2X Faster VLU healing, 87% Lower VLU recurrence rate at 36 months, Pain score dropped from 8 to 3 in 13 days:
The recommended Extremity Chamber treatment is 90 minutes, 4-5 days per week.
Benefits of Supplemental Oxygen
- TWO2® kickstarts the stalled healing process. Non-healing wounds that stall in the inflammatory phase lack adequate oxygen, which prevents essential enzymic production responsible for cellular metabolism, collagen production and immune response to fight infection.
- TWO2® provides the highest penetration of oxygen into the wounded tissue through an oxygen partial pressure of approximately 800 mmHg.
- The extra availability of oxygen provides fuel for ATP synthesis and propels the wound out of the inflammatory phase and restores a robust healing pathway.
AMPLIFIES local immune response to fight infection
- Upregulation of leukocyte function potentiates both neutrophil effectiveness and any concurrent antibiotic therapy being utilized to treat infected wounds.
As bacterial metabolism accelerates, senescent bacteria become more susceptible to these defensive mechanisms. The increased oxygen levels also have a direct bactericidal effect on any anaerobic bacteria present.
STIMULATES neovascularization
- An increase in the production of vascular endothelial growth factors (VEGF) results in prolific angiogenesis and new blood vessel growth.
Additionally, there is a synergistic effect of oxygen on the reactive oxygen species (ROS) needed for transforming growth factor beta (TGFβ) and platelet-derived growth factor (PGF).
PROMOTES stronger collagen synthesis
- TWO2® promotes the synthesis of superior quality triple-helix collagen for improved tensile strength, while healing the wound with ideal histology.
This results in little to no scarring and healthy desquamation, reducing the risk of callus formation and recurrence.
Benefits of Cyclical Compression
- The non-contact cyclical compression provided is between 7.5 and 37.5 mmHg (10 and 50 mb) pressure—equivalent to a level 3 conventional compression dressing (CCD). This helps to reduce both edema and the hydrostatic pressure in the lower leg that is a frequent component of lower extremity peripheral vascular disease.
- The higher positive pressure more effectively delivers oxygen deep into the wound bed, thereby encouraging granulation from the base.
- The cyclical nature of the pressure delivery eliminates concerns when treating ischemic wounds.
- Reduces edema
- Decreases resistance to arterial flow
- Aids the passage of nutrients to wounded tissues
- Accelerates the elimination of metabolites
- Prevents the collapse of tunnels and fistulas, avoiding the formation of abscesses
- Improves oxygen diffusion and wound bed perfusion
- Stimulates damaged end arteries to promote angiogenesis
Benefits of Humidification
- A nebulizer delivers a fine particulate mist to the chamber to create an ideal wound healing environment, which allows for fast epithelial cell migration and faster healing.
Manufacturer: AOTI USA, USA.
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